Selank — Research Summary
Overview
Selank is a synthetic heptapeptide derived from tuftsin, an immunomodulatory peptide. Developed in Russia alongside Semax, it has been studied for its anxiolytic properties and effects on cognitive function. Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic derivative of the naturally occurring immunopeptide tuftsin (threonyl-lysyl-prolyl-arginine). The addition of a Pro-Gly-Pro sequence to the C-terminus of tuftsin was designed to enhance metabolic stability while potentially preserving the immunomodulatory properties of the parent peptide. Research has examined Selank's interactions with GABAergic neurotransmission pathways and its effects on the expression of genes involved in anxiety-related behaviors in experimental models. The compound's dual characterization as both a neuropeptide and an immunomodulatory agent reflects the growing scientific understanding of neuro-immune crosstalk and the interconnected nature of nervous and immune system signaling. Preclinical studies have employed a range of behavioral paradigms, including elevated plus maze, open field testing, and conditioned avoidance assays, to characterize its effects on stress-response pathways.
Compound Profile
The following specifications characterize the Selank research compound as supplied for laboratory investigation purposes.
| Compound Name | Selank |
| Designation | Selank — 5 mg |
| Sequence / Structure | Thr-Lys-Pro-Arg-Pro-Gly-Pro (Heptapeptide, tuftsin analog) |
| Purity | ≥99% |
| Form | Lyophilized powder |
| Vial Size | 5mg |
| Storage | Refrigerated after reconstitution |
| Research Category | Neuropeptide Research |
| Series | Neuro Series |
| SKU | SK-5 |
Published Research
The following findings have been documented in peer-reviewed publications and scientific literature. These summaries reflect reported observations and are presented for informational purposes in support of laboratory research activities.
- Research published in Russian journals documented that Selank affects the expression of genes involved in GABAergic neurotransmission, which is associated with anxiety regulation.
- Studies have examined Selank's effects on anxiety-like behaviors in various animal models, with researchers noting modulation of stress-response pathways.
- Research has documented immunomodulatory properties, consistent with its derivation from the immunopeptide tuftsin.
- Clinical observations in Russia have examined Selank's effects on generalized anxiety and cognitive performance.
These findings reflect outcomes observed in controlled research settings and published study protocols. Individual experimental conditions, model organisms, and methodologies varied across studies. Results observed in preclinical and clinical research settings may not be generalizable.
Mechanism of Action
Selank is proposed to modulate GABAergic neurotransmission and influence IL-6 expression. Research suggests involvement in stress adaptation and immune system regulation pathways.
The mechanisms described above have been characterized through published research methodologies including receptor binding assays, gene expression analyses, cell culture experiments, and in vivo preclinical models. Mechanistic understanding continues to evolve as additional research is published.
Research Context
Neuropeptide research encompasses the study of short-chain peptides that have been observed to interact with central nervous system pathways, including those involved in neurotrophic factor expression, neurotransmitter modulation, and stress-response regulation. This area of investigation has grown substantially as researchers seek to understand how peptide analogs of endogenous neuropeptides may influence cognitive processes, neuroplasticity, and neuronal resilience in experimental models. The melanocortin system, GABAergic signaling, and brain-derived neurotrophic factor (BDNF) pathways have been identified as key areas of interest. Studies have been conducted using a range of experimental paradigms, including behavioral assays in animal models, electrophysiological recordings, and molecular analyses of gene expression in brain tissue. The field also examines the immunomodulatory properties of certain neuropeptides, reflecting the increasingly recognized connections between immune signaling and nervous system function.
Selank has been studied within this broader research context. The compound is classified under the Neuropeptide Research category and is part of the Neuro Series in the Hot Peps research catalog. Researchers investigating neuropeptide research may find the published findings summarized above relevant to their experimental design and literature review processes.
Key Citations
The following references represent a selection of published studies relevant to Selank research. Full-text articles may be accessed through their respective journal publishers or indexed databases such as PubMed.
- Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003;33(7):639-643
- Seredenin SB, et al. Pharmacogenetic analysis of mechanisms of emotional stress. Ann Ist Super Sanita. 1990;26(1):81-84
This compound is part of the Neuro Stack — cognitive & stress-response pathway focus.
View Kit →Important Notice
Selank is sold exclusively for in vitro research, laboratory use, and scientific investigation purposes. This compound is not intended for human consumption, veterinary use, or any therapeutic application. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition.
All research findings, statistics, and outcomes referenced on this page have been sourced from published peer-reviewed studies and scientific literature. These summaries are provided for informational purposes to support qualified researchers in their laboratory investigations. Results documented in published research were obtained under specific experimental conditions and may not be reproducible in all settings.
Researchers are responsible for ensuring that their use of research compounds complies with all applicable local, state, and federal regulations governing laboratory research materials.
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All findings referenced on this page reflect outcomes reported in published research studies. This product is sold strictly for in vitro research, laboratory use, and scientific investigation only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.