Selank
Tuftsin-Derived Immunomodulatory Heptapeptide
Selank is a synthetic heptapeptide derived from tuftsin, a naturally occurring immunomodulatory peptide. Developed alongside Semax at the Institute of Molecular Genetics in Russia, it was created by extending tuftsin's four-amino-acid sequence with a stabilizing Pro-Gly-Pro tail. This modification increased enzymatic stability while preserving the immunomodulatory properties of the parent compound. Published research has examined its effects on GABAergic neurotransmission, stress-response pathways, and immune system regulation.
Why Researchers Study It
Selank occupies a unique position in neuropeptide research because it bridges neuroscience and immunology. Derived from an immune peptide, it has documented effects on GABAergic and enkephalinergic systems — two pathways that rarely intersect in a single compound. That dual profile keeps drawing researchers who study the neuro-immune interface.
GABAergic Modulation
Research has documented that Selank affects expression of genes involved in GABAergic neurotransmission, including enzymes responsible for GABA synthesis and metabolism.
Stress-Response Pathways
Behavioral studies in rodent models documented reduced anxiety-like behaviors without the sedative effects commonly associated with benzodiazepine-class compounds.
Immunomodulatory Properties
Studies have explored Selank's effects on cytokine expression, including IL-6 modulation, connecting its tuftsin-derived structure to measurable immunological effects.
Enkephalin Degradation Research
Researchers documented that Selank inhibits enzymes involved in enkephalin degradation, suggesting an additional pathway through which it may influence stress-related signaling.
Research Timeline
8 milestones spanning 1980s–2023
- Designed by extending the immunopeptide tuftsin with a stabilizing Pro-Gly-Pro sequence (1980s)
- GABAergic mechanism research established a molecular basis for observed effects (2006–2008)
- Integrated neuro-immune studies explored dual pathway activity (2020–2023)
Related Learning
Guides, articles, and resources connected to this compound.
Neuropeptides & Cognitive Signaling
How neuropeptide analogs interact with stress-response and cognitive pathways.
Peptide Mechanisms Explained
Receptor binding, signaling cascades, and pathway interactions.
Complete Guide to Research Peptides
Comprehensive overview of the research peptide landscape.
How Peptides Work
Foundation guide covering peptide structure and signaling mechanisms.
Research Database
Searchable index of published research across all compounds.
Published Research
Selected citations from the published literature.
Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003;33(7):639-643
Seredenin SB, et al. Pharmacogenetic analysis of mechanisms of emotional stress. Ann Ist Super Sanita. 1990;26(1):81-84
Explore Selank
Research data, product specifications, and related kits.
Research Use Compliance
All information presented on this page references published preclinical research and is provided for educational and informational purposes only. These products are intended for laboratory research use only. Not for human consumption. No statements on this page have been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.