Recovery
Series

GHK-Cu — 50 mg

GHK-Cu is a naturally occurring tripeptide-copper complex first isolated from human plasma in 1973. It is found in plasma, saliva, and urine, with levels that decline with age. Research has focused on its role in wound healing and tissue remodeling.

• A comprehensive review in the International Journal of Molecular Sciences (Pickart & Margolina, 2018) documented GHK-Cu's ability to stimulate collagen synthesis, promote blood vessel and nerve outgrowth, and increase glycosaminoglycan production in multiple tissue types.
• Research published in Archives of Facial Plastic Surgery (Pollard et al., 2005) demonstrated that GHK-Cu restored replicative vitality to irradiated fibroblasts and increased secretion of growth factors including bFGF and VEGF.
• Studies in wound healing models showed that collagen dressing incorporated with GHK increased collagen synthesis 9-fold in rat wound models.
• Gene profiling studies using the Broad Institute Connectivity Map revealed that GHK can up- and downregulate over 4,000 human genes, including those involved in antioxidant response, inflammation, and tissue remodeling.

GHK-Cu is proposed to function through copper delivery to cells, gene expression modulation, and activation of multiple signaling pathways involved in tissue repair and remodeling.

• Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide. Int J Mol Sci. 2018;19(7):1987.PMID: PMC6073405
• Pollard JD, et al. Effects of Copper Tripeptide on the Growth of Fibroblasts. Arch Facial Plast Surg. 2005;7(1):27-31
• Pickart L. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015.PMID: 26236730